: epidemiology, disease progression, treatment and disease burden.
These parallel trials "have documented sustained [uric acid] reductions and significant clinical improvement in a substantial proportion of patients with chronic gout
and refractoriness to, or intolerance of, conventional urate-lowering therapy," the investigators wrote.
Progressive reduction in tophus burden wtih pegloticase therapy in patients with chronic gout
refractory to conventional therapy.
It is the only FDA-approved product specifically indicated for the treatment of chronic gout
in adult patients refractory to conventional therapy.
It won't help in diagnosing acute gout, and should only be used to evaluate bone and joint erosions in chronic gout
Former landlord Mark, who lives in Greetland, needed the transplant after being affected by chronic gout
Pegloticase, a recombinant formulation of porcine uricase, has been approved for the treatment of chronic gout
in adults who are refractory to conventional treatments.
If the patient has more than two attacks per year or one attack and also suffers from Gout, has chronic gout
, chronic kidney disease.
"In patients with chronic gout
treated with a xanthine oxidase inhibitor (allopurinol or febuxostat) to lower the serum urate" to recommended target levels below 6.0 mg/dL, "the small elevation in serum urate is unlikely to negate the clinical efficacy of these drugs when dosing is optimized," Dr.
Market growth can be attributed to the introduction of major urate-lowering agents, approval of effective biologics, and increasing number of patients suffering from chronic gout
Treatment of gout consists in the early correction of asymptomatic hyperuricemias, the treatment of the acute gout attack, the prevention of new attacks and the prevention of chronic gout
. The nonpharmacologic measures consist of putting at rest the inflicted joint during the acute attack and taking dietary choices.