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Related to circulatory overload: air embolism
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Among these complications most common reasons of mortality were graft-verses- host disease (85-100%), transfusion-associated circulatory overload (2-15%) and transfusion- associated acute lung injury (5-10%).
On the other hand when fluid was administered along with administration of spinal anesthesia (Co loading), expanded intravascular compartment is filled up as there is sympathetic block induced vasodilatation and less chance of circulatory overload.
The most obvious treatment is restoration of red cell volume by transfusions of fresh blood, but this carries with it such risks as serum hepatitis, transfusion reactions, antibody formation, and circulatory overload.

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