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When faced with the question of whether the written description would have enabled a PHOSITA at the time of filing to use cleavable fusion expression to make HGH without undue experimentation, (135) the Federal Circuit determined that it did not:
Analysis of the Msa sequence with eight signal peptide prediction programs showed a consensus that Msa has a cleavable N-terminal signal peptide that mediates its targeting into the membrane.
A cleavable crosslinker based on methacrylic anhydride was also found to be necessary for improved mechanical properties and significantly reduced the swelling of the polymer in the monomer formulation.
Functionalization of carbon nanotubes via cleavable disulfide bonds for efficient intracellular delivery of siRNA and potent gene silencing.
The products are selectively cleavable under mild conditions, and after the reaction, besides the desired product also its initial amine component can be resynthesized.
SGN-35 is an ADC comprised of an anti-CD30 antibody joined by an enzyme cleavable linker to a synthetic drug payload, monomethyl auristatin E (MMAE), using Seattle Genetics' proprietary technology.
The acquisition of a highly cleavable HA converted an avirulent strain to virulence in Pennsylvania in 1983 (H5N2), Mexico in 1994 (H5N2), Italy in 1997 (H7N1), Chile in 2002 (H7N3), and Canada in 2004 (H7N3) (Table).
Durham, today most systems use cleavable 2-alkyl-2-adamantane methacrylate copolymerized with lactone and fused ring alcohols in order to offset the high hydrophobicity of the adamantane ring.
These patients tend to have limited skin disease, are anticentromere positive, and demonstrate granzyme B cleavable autoantigens.