more unprocessed precursor compared to biosynthetic
cleavage products in severe heart failure.
When reexamined, three of the samples did contain weak
cleavage products corresponding to the expected fragment sizes when compared with cDNA sequence data but were not registered as mutated during the blind phase of the study.
In samples with the T833C mutation, the fluorescent
cleavage product is from the coding strand.
Quantitative analysis of the
cleavage products generated during the processing of amyloid precursor protein is critical to the understanding of the pathogenesis of Alzheimer's disease," said Joe Bertelsen, Neuroscience Product Manager, Signet Laboratories, Inc.
sz]-Amyloid (A[sz]) peptides are generated as
cleavage products 39 to 43 amino acids in length from the membrane protein, Amyloid Precursor Protein (APP) by two proteases, ?
Aromatic rings are dihydroxylated and then ring cleavage occurs and ultimately
cleavage products are metabolized [1,4]
Cleavage products were recovered after SDS/Proteinase K treatment.
Another method that combines immunoaffinity chromatography with specific antibodies for
cleavage products has been successful in detecting BoNT B in some foods at lower detection limits than the mouse bioassay (10).
Identical ring
cleavage products during anaerobic degradation of naphthalene, 2-methylnaphthalene, and tetralin indicate a new metabolic pathway, Appl Environ Microbiol 68(2):852-858.
The reaction is composed of 3 steps: binding of the ribozyme to the target, cleavage of the target, and release of the
cleavage products (4) (Figure).
The oxidation results in two classes of compounds: [alpha]-hydroxylation products and ring
cleavage products (Fig.
