A predominance of a single sequence will, therefore, be a mark of clonality
, an indication of malignancy.
and progression in multiple premalignant and malignant oral lesions identifies a subgroup of cases with a distinct presentation of squamous cell carcinoma.
improves diagnostic yield of TCRy clonality
in refractory celiac disease.
To evaluate molecular clonality
, three slices of 10p FFPE tissue were used for extraction of DNA according to the protocol previously described by Maria et al .
The relation between clonality
and increase in sexual reproduction was strong in C.
To examine the degree of clonality
within sampling locations, repeated genotypes were documented and inbreeding coefficients ([F.
As a measure of degree of clonality
, we calculated the genotype discovery rate between genotypes (G) and number of individuals sampled (N) (G/N) (Ellstrand & Rose, 1987; Silvertown, 2008) and the unbiased probability of identity P(ID), which corrects for deviations from HW and LD (Waits et al.
Our patient was FlP1L1-PDGFRA-negative and did not show any evidence of T or B cell clonality
studies were performed in the peripheral blood and revealed a genetic rearrangement pat-tern of the beta chain T-cell receptor (TCR-beta) and abnormal T clone in seven metaphases with loss of Y chromosome.
They cover basic principles of electrophoresis, protein constituents of serum, determining immunoglobulin clonality
and quantifying specific serum proteins, monoclonal gammopathies, urine protein electrophoresis, and a clinical approach.
At the end, an open lung biopsy with thoracotomy for interstitial lung disease and thymectomy were performed, and the pathologic diagnosis was as micronoduler type thymoma, surrounded by monoclonal B cell proliferation approved by molecular clonality
studies and also amyloid accumulation in the lung, which was shown to be AL type of amyloid by mass spectrometry (Figure 2).
Both the polymerase chain reaction (PCR) and fluorescence in situ hybridisation (FISH) identify tiny regions of DNA of interest to establish clonality
for confirmation of malignancy in a lymphoid population, or to look for characteristic translocations, deletions and gene amplifications in the DNA which are specific for certain subtypes of lymphomas.