Summary: Clotting factors
are proteins that play an important role in blood clotting.
Wild-type mice and knockout disease models were dosed with human cells genetically engineered to produce stable blood plasma levels of the clotting factors
missing in patients with hemophilia.
Imported vials of synthetically produced clotting factor
are also available in the market, but at a very high cost.
"He has a port in his chest called Freddie and I was trained in Crumlin to administer clotting factor
. He gets it twice a week, so we usually work it around his PE days in school.
Not only is accessing clotting factor
close to impossible, people often struggle to afford public transportation to the hospital to get care, or to buy ice, bandages, or painkillers to bring some relief.
Abdelbari, there are two types of treatment regimens offered to patients with hemophilia at HMC, including on-demand therapy given to control sudden bleeding into the joint or muscle and the routine administration of clotting factors
two to three times a week to prevent bleeding, known as prophylaxis.
While a drug containing the 'clotting factor
' is available from pharmaceutical firms abroad, locally it costs at least P20,000 per adult dose that should be taken
According to (https://www.mayoclinic.org/diseases-conditions/hemophilia/symptoms-causes/syc-20373327) Mayo Clinic , "Hemophilia is a rare disorder in which your blood doesn't clot normally because it lacks sufficient blood-clotting proteins (clotting factors
moderate to severe hemophilia is factor replacement therapy, which involves replacing the blood's deficient clotting factor
. He said that it can be given to stop bleeding or as preventive therapy, to keep bleeding from starting.
Alprolix is a recombinant, clotting factor
therapy developed for haemophilia B by fusing factor IX to the Fc portion of immunoglobulin G subclass 1, or IgG1 (a protein commonly found in the body).
They are classified according to which clotting factor