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Related to clotting factor: hemophilia
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The slight reduction in clotting factor XII activity (53 IU/dL; reference interval 70-150 IU/dL) was considered secondary.
The proteins in plasma include the major clotting factors and intrinsic anticoagulants.
Treatment of chronic hepatitis C with ribavirin and interferon alfa-2b in patients with hemophilia appeared to reduce patients' use of clotting factors in a small case series, reported Takashi Honda, M.
To manage the disorder, blood clotting factor is infused (injected) to replace the missing protein.
Providers incur additional costs associated with delivering clotting factor that are not separately reimbursed by Medicare.
About 3% to 4% of patients with hemophilia B, caused by a deficiency of clotting factor IX, develop inhibitors in their blood that block the efficacy of factor IX replacement therapy administered to control bleeding episodes.
The addition of a human cell is expected to enable the clones, when they grow up and reproduce, to provide milk containing a human clotting factor that can be used to heal people with haemophilia, Wong said.
Cell Genesys is pursuing gene therapies for hemophilia A and hemophilia B -- genetic deficiencies in factor VIII and factor IX clotting factor genes, respectively.
This means their blood lacks an essential clotting factor.
The incidence of von Willebrand disease - which is similar to hemophilia but different in that the deficient clotting factor does not always remain at the same level - is not known.
Other measures of rFVIIIFc's activity in the body reinforce its long-lasting characteristics: the mean time for maintaining a clotting factor activity level associated with less bleeding (time to 1 percent) was approximately 5 days for rFVIIIFc compared to 3.
Hemophilia A, also called as classical hemophilia or factor VIII deficiency hemophilia, is caused by deficiency of clotting factor VIII.