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By blocking the amplification loop of the complement alternative pathway, ACH-4471 has the potential to control intravascular hemolysis as well as prevent the development of extravascular hemolysis," said Professor Peter Browett, BMedSci, MBChB, FRACP, FRCPA; Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand.
ACH-4471 is the first factor D inhibitor to demonstrate complement alternative pathway inhibition in humans after oral dosing," said Dr.