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After IEC clearance and informed consent in patient's own language, patients were randomized by blind envelope method to receive either concomitant chemoradiation with a radiation dose of 50 Gy in conventional fractionation and concomitant weekly injection cisplatin 40 mg/[m.sup.2] as radio-sensitizer, followed by brachytherapy or two cycles of neoadjuvant chemotherapy with carboplatin AUC 6 along with injection paclitaxel 175 mg/[m.sup.2] followed by hypo-fractionated external beam radiation (42 Gy in 16 fractions over 3.5 weeks) started within 3 weeks of chemotherapy or three cycles of neoadjuvant chemotherapy with same regimen followed by concomitant chemoradiation.
An important remaining question is the safety of the concomitant surgeries.
Based on univariate analysis, multivariate logistic regression analyses of inhospital mortality showing NYHA-4 (odds ratio [ OR ]: 8.7, 95% confidence interval [ CI ]: 2.1-36.2, P = 0.003), smoking history ( OR : 3.7, 95% CI : 1.5-9.3, P = 0.005), poor EF ( OR : 5.4, 95% CI : 2.2-13.5, P < 0.001), previous cardiac surgery ( OR : 10.9, 95% CI : 2.6-46.2, P = 0.001), moderate or severe tricuspid regurgitation ( OR : 3.2, 95% CI : 1.3-8.1, P = 0.012), and concomitant CABG ( OR : 5.0, 95% CI : 1.3-19.2, P = 0.020) to be potential risk factors for short-term mortality [Table 2].{Table 2}
The purpose of this study has been to evaluate the frequency and the risk of concomitant sensitization to some methacrylic monomers and to glutaraldehyde among students of dental medicine and those from the dental technician school, and dental professionals.
With the development of new evidence surrounding the epidemiological interaction between organisms (21) we aimed to identify current cases of concomitant infection described in the literature and review current evidence in support of each epidemiological theory.
Ideally, large randomized trials comparing NSAIDs with and without a concomitant medication would inform our assessment of risk.
The 8p11 myeloproliferative syndrome is one of these rare disorders in which patients usually present with concomitant or sequential development of a myeloid and lymphoid malignancy.2
Then the effect of age on the rate of multiple concomitant metastatic sites was tested in the entire population, and according to the 5 most common metastatic sites and to brain metastases.
Similar observations have been reported in the treatment of inflammatory bowel disease, where early use of infliximab monotherapy has given way to a standard of care that includes concomitant immunosuppressives.
pylori eradication by concomitant therapy with four proton pump inhibitors―lansoprazole, omeprazole, rabeprazole sodium and esomeprazole magnesium hydrate-manufactured and marketed by the four companies in Japan under five brand names.