Disruption of the PPO enzyme in humans is rare but is known to cause porphyria, a group of congenital diseases
that in one form, known as "variegate porphyria," can cause symptoms that include temporary paralysis of limbs, sensitivity to light, seizures, hallucinations, and other neuropsychiatric problems.
This was partially answered by the Stanley group's finding that a deadly congenital disease
, hyperinsulinism/hyperammonemia (HHS), is caused by the loss of some of this regulation.
women with congenital heart disease during the study period matched their pregnant counterparts without congenital disease
by their average age, 27, but their risk for peripartum complications or death was far higher, said Dr.
Davies said the new analysis of UNOS data, based on transplantations performed from 1995 to 2008, suggests that adult congenital patients have four times the risk of dying within 30 days of surgery compared with adult heart transplant recipients without congenital disease
, independently of whether the latter group have a history of surgery that required sternotomy.
Secondary maternal cytomegalovirus infection--a significant cause of congenital disease
Two weeks after being surgically transplanted into either fetal or newborn rats with a congenital disease
identical to the rare human myelin disorder Pelizaeus-Merzbacher disease, the laboratory-grown cells had developed into numerous myelin sheaths around nerve fibers previously without myelin.
Spina bifida, a congenital disease
of the spinal column, is considered the nation's to crippler of newborn children.
However, opponents have argued that there are other alternatives for treatment of infertility and congenital disease
besides research on human embryos, and that the government proposal gives greater protection to experimental animals than to human embryos.
Borges's eyesight, affected by a congenital disease
, deteriorated radically in the 1950s; by 1970 he was almost totally blind and had to rely entirely on dictation for his writing.
17 Complications of development and congenital disease
He clarified that there was no known reason for this occurrence, and that these incidences are categorised as a congenital disease
Hsu believes the findings contribute to an emerging field involving tissue engineering that uses stem cells and other materials to invent superior ways to replace damaged craniofacial bones in humans due to congenital disease
, trauma, or cancer surgery.