Amatoxins, especially ?-amanitin, featured by specific MOA and high water solubility are mainly two popular ADC payloads at Creative Biolabs while Thailanstatin A is another one, modified with the installation of a N-hydroxysuccinimide (NHS) ester and successfully conjugated to Trastuzumab via amine-based lysine conjugation
to generate a virtually "linkerless" ADC.
Last June, WuXi Biologics announced the building of an integrated biologics conjugation
solution center, including process development and clinical manufacturing for Antibody-Drug Conjugates (ADCs) drug substance and drug product.
GlycoConnect is the conjugation
technology that exploits the native glycan for site-specific and stable payload attachment.
LegoChem Biosciences' ConjuAll is a next-generation ADC platform technology utilizing novel linker chemistry combined with site-specific enzymatic conjugation
. Its platform provides solutions for site-specific conjugation
, linker stability and efficient payload release which are three major unmet needs in ADC development.
The successful development of targeted nanoscaffolds is contingent upon the conjugation
of nanoparticles to target-specific ligands, especially protein-based ligands.
Uzbekistan proposes to discuss the conjugation
of the South Korean "New Northern Policy" strategy, China's "One Belt - One Way" initiative and the EU's strategy to improve the interconnection of Europe and Asia, Podrobno.uz quoted Vladimir Norov, the Director of the Institute for Strategic and Regional Studies (ISRS) under the President of Uzbekistan, during a speech at the International "Forum Korea-Asia 2018" Conference in Seoul.
This is because of lack of reproducibility across lots, poor conjugation
quality, low binding affinity, and non-specific staining--something this portfolio of reagents does not have to worry about.
"We could have turned into a province in China if we did not join the Eurasian Economic Union," economist Jumakadyr Akeneyev said on May 23 during the round table discussion "Big Eurasian partnership: conjugation
of the EAEU with the Belt and Road initiative."
The UV spectra of all compounds 2-8 showed absorption peaks in the region of 262-300 nm which was the result of extended conjugation
towards longer wavelength due to n-I* transition.
SGN-CD48A uses the company's latest ADC technology advancement, a PEGylated glucuronide linker that improves stability, reduces off-target uptake, and enables conjugation
of more molecules of the microtubule-disrupting cytotoxic agent monomethyl auristatin E per antibody.
would transfer ESBL determining plasmid from donor (Cefotaxime Resistant-[Ctx.sup.R]) to recipient (Streptomycin Resistant-[Str.sup.R]) and the resultant product (Transconjugant) would hence be phenotypically [Str.sup.R] [Ctx.sup.R].
"Taa Marbouta" refers to an Arabic alphabet that indicates the feminine conjugation
in the Arabic language.