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In the literature, it was reported that infants who were fed individualized enteral protein supplementation had better weight gain, higher increase in head circumference, and increased mental and psychomotor developmental scores at 18 months corrected age.17 In fact, in this study, the target BUN levels were between five and nine mg/dL, and these levels were lower than the BUN levels reported by Arslanoglu et al.13,17 In our study, we did not find any significant difference between the two groups in growth parameters at one year corrected age.
At 3 months of corrected age, babies whose length is less than 3rd centile consisted of 73.7% of ELBW babies and 26.3% of VLBW babies.
All enrolled infants were followed up weekly/biweekly till they were 40 weeks of gestational age, and then at 3, 6, and 9 months and within 15 months of corrected age.
There were no differences in GA, BBW, or PMA at IVI, and corrected age at refraction and biometry was noted between the two groups (Table 2).
As shown in Table 5, vertical chewing, "munching", appeared earlier in preterm infants (3 months of corrected age) compared to the appearance at 5 months in the full-term infants group.
The highest percentage of infants with severe (8.7%) and medium risk (62.8%) was at three month corrected age (Table 1).
All subjects, between the 35th and the 40th week of corrected age, were then submitted to a predischarge evaluation of the "synactive" type (i.e., based on the evaluation of the five functional subsystems described in her "synactive theory" by Als [13]: the autonomic system, the motor system, the state organizational system, the attentional-interactive system, and the self-regulatory system) by a dedicated staff composed of a child neurologist and a neonatologist.
The variables of weight, length, and head circumference were examined retrospectively through chart review at discharge, 6, and 12 months corrected age. These data collection points were selected to determine whether ELBW infants demonstrate catch-up growth during the first year of life.
Gender, corrected age, gestational week, birth weight, height, head circumference, APGAR scores in the 1st and 5th hours, presence of congenital anomaly, histroy of hospitalization and reasons, hospitalization levels (1st, 2nd and 3rd level), hospitalization time, requirement for intensive care, mecahnical ventilation support and/or requirement for surfactant, cranial ultrasonography and magnetic resonance imaging findings in the preterm babies were evaluated and recorded.
Infants were examined at 6 months' and, in the high-risk group only, at 9 months' corrected age for visual acuity, ocular motility, and ocular alignment.
Infants fed exclusively breast milk to term corrected age served as controls.
The investigators reported that 47% of the babies in the indomethacin group and 46% in the placebo group either died by 18 months corrected age or survived with neurosensory impairment.