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In present study, cylindruria revealed different types of casts such as hyaline, granular, leukocyte and epithelial.
Because the mechanism of nephrotoxicity involves proximal tubule injury, the first signs of this toxicity are proteinuria, cylindruria, and a reduction in concentrating ability (12, 57, 86-90).
In clinic manifestations, the 5 cases had multiple-system involvements, mainly renal system (5/5), manifesting in hematuria (gross hematuria 2 cases, microhematuria 3 cases), proteinuria (5/5), pyuria (2/5), cylindruria (4/5), renal dysfunction (2/5), and edema (2/5).