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the real-time deformability cytometry (rt-dc) system will be based on disposable microfluidic variable geometry (15 microns-40 microns) chips to measure cells of different sizes.
A study39 showed that an increased RDW is significantly and positively associated with decreased erythrocyte deformability (p<0.003).
Qu's lab performed additional experiments to pin down how the loss of Ptpn21 affects cell deformability. They found they could make cells lacking Ptpn21 stiff again by interfering with the function of another protein, Septin1.
They reasoned that the use of fluted pumpkin extract as an anti-sickling agent will promote flexibility of sickle red blood cells and prevent loss of cellular deformability which can compromise the ability of the red cell to optimally perform its function of oxygen delivery to the tissues.
From spinning point of view, bigger droplets manifest higher deformability and also spinnability [45-48].
Score 2, deformability of large amount of lesion with little stiff areas (Figure 3);
Deformability is one of the key physiological and biophysical indicators of RBC [1].
The IB-LBM has also been used to numerically investigate the effect of the RBC deformability on the dispersion of the cells at physiological flow rates with respect to the hematocrit [28].
It is known that the relative content of cholesterol and phospholipids (with polyunsaturated fatty acids), which depends on blood lipid levels, is essential for maintaining the fluidity, deformability, stability, and functionality of erythrocytes [22].
The skeleton curve of Specimen Q-1 shows a peak load at a drift ratio of 0.2% and rapid degradation in strength properties with increasing displacement, which indicates that Specimen Q-1 did not perform as well as other three walls in terms of bearing capacity and deformability capacity.
Specifically, it has been assessed in a preliminary study [22, 23] that the simulation of the deformability of both seat and restraint system, which cannot be accomplished by means of the MB method, influences significantly the kinematics of the ATD during the seat sled test.
A possible explanation for the change in sensitivity would be that the exit of the hole provides a free surface for the specimen with a hole and allows the specimen to have better deformability. It is less sensitive to strain rate, and with the increase in the confining pressure, the deformability caused by the free surface had become smaller.