Degrade

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TO DEGRADE, DEGRADING. To, sink or lower a person in the estimation of the public.
     2. As a man's character is of great importance to him, and it is his interest to retain the good opinion of all mankind, when he is a witness, he cannot be compelled to disclose any matter which would tend to disgrace or degrade him, 13 How. St. Tr. 17, 334, 16 How. St. Tr. 161. A question having that tendency, however, may be asked, and, in such case, when the witness chooses to answer it, the answer is conclusive. 1 Phil. Ev. 269; R. & M. 383.

References in periodicals archive ?
In this study, we found many potential lignocellulolytic degraders harbouring many different catalytic domains (up to 14 different catalytic domains) that function for all lignocellulose pretreatment and hemicellulose, cellulose saccharification.
(1998) found higher polycyclic aromatic hydrocarbon degraders in a hydrocarbon-contaminated site when compared to an adjacent, non-contaminated site.
'ARV-471 is a potent ER degrader that has demonstrated significant anti-tumor activity in preclinical models, and we are hopeful it will address an important need for patients with advanced ER positive breast cancer not adequately treated with current standards of care,' said Ronald Peck, M.D., Chief Medical Officer of Arvinas.
The unconditional degrader strains were tested for the ability to utilize various components of crude oil.
Ces routes recentes que vous voyez se degrader, c'est a cause des poids-lourds.
Of note, we will report the first clinical data from approximately 25 patients in a Phase 1 trial of G1T48, our oral selective estrogen receptor degrader. Based on data from this trial, we are planning to initiate a pivotal trial in 2020 with G1T48 for the treatment of ER+, HER2- breast cancer in combination with a CDK4/6 inhibitor.'
Arvinas announced it will present preclinical data from its tau-targeted PROTAC protein degrader program at the Alzheimer's Association International Conference.
Summary: 77% des Tunisiens estiment que la situation economique continue de se degrader alors que 15, 37% pensent le contraire, selon le Barometre politique d'Emrhod consulting du mois de decembre.
La balance commerciale n'en finit pas de se degrader. A fin juin, le deficit s'est aggrave pour atteindre 100,6 milliards de DH contre 93,5 milliards durant le premier trimestre de 2017.
Ce cout de production, qui constitue un indicateur interessant, "reste insuffisant, a toutefois indique Haoua Sais Amrouni, faisant savoir que les couts de commercialisation (transport et conditionnement) "peuvent degrader l'avantage acquis dans la production".
Tenders are invited for Supply of biological odor controller and waste degrader
Music Break Thru Music Presents Battle For Warped Tour - Round 3 with special guests Woe To The Conquered, Disowned, Degrader, Distinctions, Letting Go, Pinnacle, Premier, 11th Hour, 21st Century Fugitives, 6 p.m.