Kaneyama et al., "Ameliorating effects of anti-Dll4 mAb on Theiler's murine encephalomyelitis virus-induced demyelinating disease
," International Immunology, vol.
Multifocal involvement strongly favors non-neoplastic lesions, such as demyelinating diseases
. (1) Some examples are discussed below.
Multiple sclerosis, and other primarily demyelinating diseases
, such as myelinoclastic diffuse sclerosis (Schilder disease) and acute disseminated encephalomyelitis can manifest as tumefactive lesions.
More long-term studies examining bigger patient series should be performed to enlighten the relationship between demyelinating diseases
Overall, 65 subjects or 67.7% tested positive out of 96 patients with idiopathic inflammatory demyelinating disease
at high risk for NMO/NMOSD.
PML is a rare demyelinating disease
characterized by the lytic infection of glial cells and is often fatal.
There are no formal guidelines to specify when treatment failure or resistance to therapy occurs; this distinction is based on the neurologist's experience with demyelinating disease
and the overall impression of the patient's condition based on that knowledge.
as the assumed cause of hearing loss and vertigo.
Idiopathic inflammatory demyelinating diseases
(IIDDs) constitute a group of disorders characterized by inflammatory lesions, those are associated with loss of myelin and eventually axonal damage.[sup] Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are the most studied subgroups of IIDDs.
"The principal diagnostic consideration is whether the patient has a nonrecurrent demyelinating disease
or will ultimately prove to have the recurrent disease process we designate as MS," according to the AAN report.
CHAMPS indicates that once-weekly treatment with intramuscular Avonex injections is beneficial in people with a first presentation of demyelinating disease
who are at high risk for developing clinically definite MS.
Multiple sclerosis (MS) is an inflammatory demyelinating disease
of the central nervous system (CNS), which is characterized by multifocal plaque-like lesions that attack the myelin sheath, the protective covering for the nerve cells.