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Various SSRIs, (13), (14) TCAs, (10), (15), (16) citalopram-olanzapine combination, naltrexone, citalopram-clonazepam combination, (17) and fluoxetine-buspirone combination (18) have been studied as treatment for depersonalization disorder.
20) High doses of opioid antagonists, such as naltrexone, have been used successfully to treat depersonalization symptoms in patients with borderline personality disorder, (21) PTSD, (22) and depersonalization disorder.
More recently, minocycline has also been listed as an exacerbating factor of depersonalization disorder in Simeon et al's (2) study of the phenomenology, associated psychopathology, and treatment history in 30 consecutively recruited adults with this condition.
Since both disorders are exacerbated by caffeine administration, Stein and Uhde (21) hypothesized that depersonalization disorder might share a common pathophysiology with panic disorder.
A study of 117 patients with depersonalization disorder also showed that stress, negative affects, threatening social interaction, alcohol and drugs, and sleep deprivation were the most common exacerbating factors and that patients were most likely to be helped by relaxation, intense emotional or physical stimulation, positive social interaction, or task-focusing activities, said Dr.