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Intracellular glutathione is another detoxification mechanism that is necessary for depurative action at the cellular level.
All this confirms the additional role of St Mary's thistle as a depurative along with its traditional role as an antioxidant and hepatoprotective.
8 fold increase of intestinal P-glycoprotein (Durr 2000), therefore acting as a depurative on a number of levels.
Glastonbury (2003) concluded that even though no literature classified Hypericum as a depurative, it did have the same ability to remove zenotoxins and unwanted cellular metabolites from the cell, which meant that after examining the scientific rationale Hypericum was one of those herbs mentioned earlier that could be reclassified as a depurative.
Where St Mary's thistle and St John's wort are listed as depuratives according to the current research, berberine containing herbs are an example of a modern day perspective confirming traditional use on skin conditions.
Therefore relating this to the modern day depurative use, the P-glycoprotein can transport the berberine through the cell membranes and through over expression can increase the efficient removal of the toxins from the cell that have caused the skin condition to occur.