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Trials of other dipeptidyl peptidase-4 inhibitors have shown evidence of an increased risk of heart failure, specifically with saxagliptin in the SAVOR-TIMI 53 trial and alogliptin in EXAMINE, so a lot is riding on TECOS.
BI 1356 belongs to the distinctive class of antidiabetic compounds - dipeptidyl peptidase-4 inhibitors (DPP-4 inhibitors).
LISBON--A new meta-analysis offers some tantalizing hints that dipeptidyl peptidase-4 inhibitors may offer some level of protection against major cardiovascular events in type 2 diabetes patients.

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