distinguished by nature

See: distinct
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Thus we behold Kentucke, lately an howling wilderness, the habitation of savages and wild beasts, become a fruitful field; this region, so favourably distinguished by nature, now become the habitation of civilization, at a period unparalleled in history, in the midst of a raging war, and under all the disadvantages of emigration to a country so remote from the inhabited parts of the continent.
However much the language of the Declaration owes to John Locke, for example, to understand as self-evident the proposition that "all men are created equal" requires the common sense that tells us that no man is distinguished by nature in such a way that his right to rule another human being is akin to his right to rule, say, his horse.

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