Effect of various drug combinations
on the Red blood cells (RBC'S) count of horses [Mean Values]
The Presage platform provides previously inaccessible knowledge about interactions between drugs and living tumors, allowing for the selection and optimization of promising drug combinations
much earlier in the drug development process," said Nathan Caffo, President of Presage Biosciences.
The researchers, during the study, tested a small subset of the possible drug combinations
identified using the algorithms in two biological model systems.
Moderate AD: first and second-choice drug combinations
of two or more of the drug classes Cholinesterase Inhibitors; NMDA Receptor Antagonist; Nootropics; Colostrinin; Vitamins and other drugs for the treatment of moderate disease.
Still, initial signs indicate that unless the virus acquires resistance to the new drug combinations
, infection with the AIDS virus may be on the verge of becoming a manageable disease, but one that will be far harder to manage than, say, diabetes.
However, patients rarely take this drug combination
because it isn't as effective as other multidrug therapies that are now the standard of care, Lisziewicz says.
In previous years, the panel determined that preclinical and clinical trial data should include evidence of safety, efficacy, stability and compatibility with drug delivery systems, and, in the case of drug combinations
, drug-drug stability.
Such drug combinations
have helped slow the rate at which HIV-positive people develop AIDS and have reduced the number of AIDS-related deaths in the United States from 21,460 in the first half of 1996 to 12,040 in the first half of 1997, reported Kevin M.
President Clinton said he would ask Congress for $52 million more to cover prescriptions for the new drugs and drug combinations
for those who cannot afford them.
Additivity was observed with all other drug combinations
tested, including atazanavir, and there was no evidence of antagonism between bevirimat and any approved drugs tested in these studies.
Scientists believe the new drug combinations
may confound HIV's ability to rapidly mutate resistant strains.
Such was the case with an unusual anti-AIDS strategy proposed last Februan) Researchers studying the effects of various drug combinations
on HIV replication in cells grown in the laboratory discovered that sometimes, as the virus evolves resistance to these drugs, it also becomes less able to survive.