References in periodicals archive ?
Bolton, "6-Thioguanine alters the structure and stability of duplex DNA and inhibits quadruplex DNA formation," Nucleic Acids Research, vol.
Burrows, "G-quadruplex folds of the human telomere sequence alter the site reactivity and reaction pathway of guanine oxidation compared to duplex DNA," Chemical Research in Toxicology, vol.
Water depletion is known to stabilize a GQ (and destabilize duplex DNAs) [29, 30].
While p[y.sup.8]A decreased the stability of duplex DNAs, it markedly elevated the thermal stability of the tetramolecular structures, assumingly, due to a prevalent glycosidic syn conformation [43, 45].
We have reformulated the definition described for duplex DNAs to be suitable for GQs as well: two or more lesions within a four-stranded, two- or three-tetrad core GQ unit consisting of up to 21 nucleotides in the core.
This indicates that poly A*T base pairing in duplex DNA is affected by the presence of 3 in Sequence 1, but not in Sequence 2, suggesting a sequence dependent effect on duplex structure by the presence of a single 3.
In duplex DNA, the presence of 3 causes the characteristic poly A*T shoulder to be lost in the CD spectra of 1D, but maintained in 2D.If 3 affects base-pairing interactions in both the 5 and 3 directions, it is expected that both duplex constructs of Sequences 1 and 2 containing 3 would lose the poly A*T shoulder in the CD spectra.
Differential scanning calorimetry of C3'-thymidinyl radical derived single strand-break products of the model replication fork was performed to thermodynamically characterize the effects of OvHgs and phosphates on the core duplex DNA as indicated in Table 3.
de los Santos, "Structure and stability of duplex DNA containing (5'S)-5', 8-cyclo-2'-deoxyadenosine: an oxidatively generated lesion repaired by NER," Chemical Research in Toxicology, vol.
Ren et al., "Experimental measurement of aromatic stacking affinities in the context of duplex DNA," Journal of the American Chemical Society, vol.