If response reduction persists under these conditions, it would appear that stimulus conditions are responsible for the effects of the durable response
reduction observed in Experiment 1.
Differences in durable response
rates and overall response rates between the T-VEC and GM-CSF arms were greater among patients with stage IIIb or IIIc (33% vs.
In 1975, when dacarbazine became the standard of care for metastatic melanoma, it was associated with response rates of only about 6%-15%, durable responses
in only 5%15% of patients, and a median overall survival of about 6-9 months, Dr.
An initial analysis supports durvalumabs clinical activity, with durable responses
and an established safety profile in these difficult-to-treat patients.
Final data on survival and durable response
from AGENDA, which may be pivotal for regulatory approval, are expected in the first half of 2011.
Measures of clinical efficacy also showed durable responses
during the second year of therapy, Dr.
However, the sole randomized comparative trial to date as well as other evidence suggests cognitive behavioral therapy (CBT) has a higher response rate than SSRIs, achieves larger reductions in symptoms, and provides more durable responses
In the study, MOR106 showed first signs of activity and durable responses
and was generally well tolerated in AD patients.
NASDAQ: TOCA) has released updated data demonstrating long-term durable responses
, and the conversion of initial partial responses (PRs) into complete responses (CRs), from a Phase 1 study of Tocagen's investigational product, Toca 511, followed by Toca FC, for the treatment of patients with recurrent high-grade glioma (HGG), the company said.
AVELUMAB (BAVENCIO) elicited durable responses
in a phase II study of patients with Merkel cell carcinoma, reported at the annual meeting of the American Association for Cancer Research.
Such therapies, referred to as immunotherapies, are now beginning to revolutionize the treatment of some cancers, yielding both remarkable and durable responses
Extensive clinical studies of ZEVALIN have confirmed high response rates and durable responses
in patients with relapsed, refractory follicular or transformed B-cell NHL.