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However, as enamel maturation in the FPM takes several years (later maturation stage), hypomineralisations may develop later.
However, although the main effect is thought to be on enamel maturation there is also evidence to suggest that continuous intake of F during and after the secretory phase may also increase fluorosis risk [Aoba and Fejerskov, 2002].
The development of enamel opacities implies that ameloblasts are affected during the enamel maturation stage.