maturation

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(41, 42) However, experimental studies on fluorosis have focused specifically on the stage of enamel maturation (which includes the orderly sequence of crystal growth, proteolytic digestion by different enzymes, and absorption of protein residues), as it has proven to be the most sensitive to the negative effects of F-.
GAGs regulate the enamel maturation during the transitional and maturation stage of amelogenesis.
Current research suggests that superfluous amounts of fluoride cause retention of amelogenin proteins in the developing tooth structure, there by inhibiting enamel maturation. This interference results in porosities in the enamel at the time of tooth eruption.