Characterization of human primary enamel organ
epithelial cells in vitro.
In the center of the islands, loosely organized cells were found, resembling the stellate reticulum of the enamel organ
The tumor is made up of a blend of ameloblasts and epithelial cells that try to duplicate the enamel organ
It is considered to arise during the morpho-differentiation stage of tooth development, as a result of out folding of the enamel organ
or hyper productivity of the dental lamina.
The inner and outer enamel epithelium proliferate from the cervical loop of the enamel organ
and make a doubled layer of cells named Hertwig's epithelial sheath.
Ameloblastoma can originate in the dental lamina (or its derivatives, such as epithelial rests), in the epithelial lining of odontogenic cysts, in basal cells of the surface epithelium, and in epithelium of the enamel organ
The developmental anomalies that represent an infolding of the enamel organ
and the epithelial sheath of Hertwig are known by various names namely the palatogingival grooves, radicular lingual grooves, palatal radicular grooves, radicular palatal grooves, distolingual grooves or radicular gingival grooves.
Majority of palato gingival grooves affect maxillary lateral incisors and may result from an infolding of the enamel organ
and Hertwig's epithelial root sheath (HERS).