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Such patients, identifiable by an LV end-diastolic pressure greater than 18 mm Hg, accounted for roughly 40% of the study population.
The thick ventricle wall causes a decrease in diastolic ventricular compliance and therefore end-diastolic pressure must increase in order to perpetuate the same end-diastolic volume (13,14).
End-diastolic pressure is decreased from 50 mmHg (point D1), to 35 mmHg in point D2, when IABP is applied.
In hypertensive and/or diabetic heart disease (27-32) as well as in hypertrophic cardiomyopathy and other diseases causing increase of left ventricular mass (33-34),the involvement of left atrium is early and it descends from propagation of high levels of LV end-diastolic pressure (3537), which are faithfully reproduced by Doppler velocimetric pattern found in these cases, characterized by E/A ratio >2 and deceleration time(DT)<120 msec, so-called "restrictive left ventricular filling pattern" or RFP (38).
Left ventricular end-diastolic pressure, left atrial pressure (LAP) and pulmonary capillary wedge pressure has been the subject of many investigations.