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When patients with known coronary artery disease are compared with those without disease, exercise stress testing increases all variables to the same degree at peak exercise except end-diastolic volume.
For clinical purposes, left ventricular preload is usually defined in terms of left ventricular end-diastolic volume.
Global end-diastolic volume and cardiac function index may be useful additional measures of left ventricular preload and myocardial contractility in patients with severe left ventricular dysfunction.
Those results showed that an implanted resynchronization device could cut the death rate by 27%, and the rate of death or hospitalization for worsening heart failure by 40%, in patients with a left ventricular ejection fraction of less than 35%, a left ventricular end-diastolic volume of at least 55 mm, a QRS interval of at least 130 msec, and a 6-minute walking distance of no more than 450 m.
Measurements of left ventricular end-diastolic volume had a scatter of 16 mL when measured with 3D echo, compared with scatters of 35 mL and 37 mL for one- and two-dimensional echo.
The thick ventricle wall causes a decrease in diastolic ventricular compliance and therefore end-diastolic pressure must increase in order to perpetuate the same end-diastolic volume (13,14).