Although RHD mRNA has been detected in fetal erythroid cells
isolated from maternal circulation (6,7), we found no RHD mRNA in maternal plasma.
The pathogenesis of suspected pure red cell aplasia involves several mechanisms: immunoglobulins directed against erythropoietin or the cells themselves; T-cell cytokines blocking response to erythropoietin, particularly in chronic lymphocytic leukemia-related aplasia; and direct lysis of erythroid cells
by a virus.
In the bone marrow, monocytic elements may be somewhat less mature than in the peripheral blood, and phagocytosis of platelets, other white cells, and erythroid cells
may be apparent.
The KellBenx process involves the enrichment of FNRBC's with the antibodies licensed from AdnaGen, namely Monoclonal Antibodies with Specificity for Fetal Erythroid Cells
, to perform chromosomal or genetic analysis to identify markers of potential disorders.
Sangamo Abstracts at ASH Pertinent to Sangamo's Programs in Hemoglobinopathies Abstract#433-- Using Forced Chromatin Looping to Overcome Developmental Silencing of Embryonic and Fetal Beta-Type Globin Genes in Adult Erythroid Cells
Oral Session 112: Thalassemia and Globin Gene Regulation: Targeted Engineering of Globin Gene Expression Monday, December 9, 2013: 2:45 PM
However, differentiation of stage-specific expression of p38 MAPK isoforms has been shown in primary human erythroid cells
Identification of a ferro-reductase required for efficient transferrin-dependent iron uptake in erythroid cells
In summary, these mechanisms initiate a decreased iron concentration in the circulation, thereby limiting iron availability for erythroid cells
gamma]-Globin is synthesized in fetal erythroid cells
as a component of fetal hemoglobin (hemoglobin F) (5), and [gamma]-globin mRNA has also been used to identify fetal erythroblasts in blood samples of pregnant women (6).
The proportions of several other morphologically identifiable hemopoietic and immune cell populations (non-NK lymphocytes, nucleated erythroid cells
, monocytes and myeloid (granulocytic) cells, in both their precursor and mature forms) were also obtained by means of light microscopy (x100) 00) by well-established lineage identification techniques (Miller and Osmond, 1974, 1975; Miller et al.
Friend erythroleukemia cells are primitive erythroid cells
that can be induced to differentiate after exposure to either DMSO or hexamethylene bis-acetamide (HMBA).
Hydroxyurea increases fetal hemoglobin in cultured erythroid cells
derived from normal individuals and patients with sickle cell anemia or beta-thalassemia.