Maturation of erythroid cells
started with the expression of CD71 ([CD71.sup.+]/[Ter119.sup.-] cells) in the proerythroblasts.
Since [beta]-thalassemia cells exhibit a high level of oxidative stress, which eventually shorten the survival of erythroid cells
in [beta]-thalassemia patients, resveratrol which exhibits both antioxidant activity and HbF inducing property can become a very promising HbF inducer from the natural world 74].
Overexpressing the miR-155 in K562 cells decreased the differentiation of megakaryocyte and erythroid cells
by regulating the targets Meis-1 and Ets-1 .
Morsilli et al., "MicroRNA-486-3p regulates [gamma]-globin expression in human erythroid cells
by directly modulating BCL11A," PLoS ONE, vol.
The copper containing enzyme activity of cytochrome C oxidase (EC 22.214.171.124) may have also been reduced in liver hepatocytes and bone marrow erythroid cells
resulting in impaired haem synthesis for erythropoiesis .
Further studies to elucidate the complete structure of Hb expressed in nonerythroid cells and whether it varies from the Hb found in the erythroid cells
need further confirmation.
However, expression of [gamma]-globin is not a fetus-specific phenomenon and is shared by maternal erythroid cells
(5), and [gamma]-globin mRNA is readily detectable in non-pregnant individuals (4).
The bone marrow aspiration showed severe hypocellularity secondary to a marked decrease in megacaryocytes, granulocytes, and erythroid cells
; the morphology of the marrow elements was normal.
A 5' element of the chicken beta-globin domain serves as an insulator in human erythroid cells
and protects against position effect in Drosophila.
The cells stained with CD31 (figure, B) and glycophorin, which indicated the presence of a mixture of megakaryocytic and erythroid cells
. These findings suggested a diagnosis of extramedullary hematopoiesis.
Regulation of cellular iron metabolism by erythropoietin: Activation of iron-regulatory protein and upregulation of transferrin receptor expression in erythroid cells
. Blood, 89, 680-687.
Haematopoiesis relates to the development of three important lineages: Lymphocytes, myelocytes and erythroid cells
. This project will study the longitudinal effects of drug and stem cell transplant on this system using mathematical modelling to investigate two key stumbling blocks in drug development of agents affecting the haematiopoietic system: Ascertaining human expected effect from pre-clinical animal data; and predicting haematopoietic drug effects in children.