It is a DNA-binding drug which has the potential to induce [gamma]-globin mRNA accumulation and HbF production in erythroid cells
from healthy human subjects as well as [beta]-thalassemia patients .
5 g/dl, RET 28 x 10 [sup]9 /L; bone marrow smear showed mature lymphocytes of 21%, granulocytic cells 71%; erythroid cells
7% and M/E ratio 10.
Differentiation stage-specific activation of p38 mitogen-activated protein kinase isoforms in primary human erythroid cells
STEAP3 Six transmembrane epithelial Hephaestin antigen of the prostate-3, is an endosomal ferrireductase responsible for the uptake of TF-bound iron in erythroid cells
Quantitative PCR analysis of HbF inducers in primary human adult erythroid cells
39 Precursor Nucleated Myeloid Cells Erythroid Cells
The bone marrow in CNL is hypercellular and myeloid, and usually has an myeloid to erythroid cell
ratio that varies between 5:1 and 25:1 (normal ratios are 2:1 to 5:1).
Circulating fetal cells include lymphoid, myeloid precursors, erythroid cells
and epithelial (trophoblastic) cells.
13) For example, by diminishing colony formation of burst-forming unit erythroid cells
and colony-forming unit erythroid cells
, interferon [gamma] and tumor necrosis factor a can exacerbate anemia.
Although this result may serve to indicate that exposure to the maternal environment leads to the induction of apoptosis in fetal NRBCs, it fails to take into account several recent reports suggesting that the terminal differentiation of erythroid cells
uses apoptotic mechanisms to facilitate enucleation (9,10).
Renal failure patients are deficient in EPO, which normally acts to increase the number of cell-surface transferrin receptors in erythroid cells
(RBCs and their progenitors) (Weiss et al.
require more iron than any other cell in the body.