Maturation of
erythroid cells started with the expression of CD71 ([CD71.sup.+]/[Ter119.sup.-] cells) in the proerythroblasts.
Since [beta]-thalassemia cells exhibit a high level of oxidative stress, which eventually shorten the survival of
erythroid cells in [beta]-thalassemia patients, resveratrol which exhibits both antioxidant activity and HbF inducing property can become a very promising HbF inducer from the natural world 74].
Overexpressing the miR-155 in K562 cells decreased the differentiation of megakaryocyte and
erythroid cells by regulating the targets Meis-1 and Ets-1 [44].
Morsilli et al., "MicroRNA-486-3p regulates [gamma]-globin expression in human
erythroid cells by directly modulating BCL11A," PLoS ONE, vol.
The copper containing enzyme activity of cytochrome C oxidase (EC 1.9.3.1) may have also been reduced in liver hepatocytes and bone marrow
erythroid cells resulting in impaired haem synthesis for erythropoiesis [4].
Further studies to elucidate the complete structure of Hb expressed in nonerythroid cells and whether it varies from the Hb found in the
erythroid cells need further confirmation.
However, expression of [gamma]-globin is not a fetus-specific phenomenon and is shared by maternal
erythroid cells (5), and [gamma]-globin mRNA is readily detectable in non-pregnant individuals (4).
The bone marrow aspiration showed severe hypocellularity secondary to a marked decrease in megacaryocytes, granulocytes, and
erythroid cells; the morphology of the marrow elements was normal.
A 5' element of the chicken beta-globin domain serves as an insulator in human
erythroid cells and protects against position effect in Drosophila.
The cells stained with CD31 (figure, B) and glycophorin, which indicated the presence of a mixture of megakaryocytic and
erythroid cells. These findings suggested a diagnosis of extramedullary hematopoiesis.
Regulation of cellular iron metabolism by erythropoietin: Activation of iron-regulatory protein and upregulation of transferrin receptor expression in
erythroid cells. Blood, 89, 680-687.
Haematopoiesis relates to the development of three important lineages: Lymphocytes, myelocytes and
erythroid cells. This project will study the longitudinal effects of drug and stem cell transplant on this system using mathematical modelling to investigate two key stumbling blocks in drug development of agents affecting the haematiopoietic system: Ascertaining human expected effect from pre-clinical animal data; and predicting haematopoietic drug effects in children.
