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Akaike, "Contribution of the Na-K-Cl cotransporter on GABAA receptor-mediated presynaptic depolarization in excitatory nerve terminals," Journal of Neuroscience, vol.
The unseen malfunction behind these effects is the abnormal firing of many excitatory nerve cells in the brain at the same time.
Excitatory nerves cause fiber depolarization, contraction of the valves, and reduction in LAA outflow.

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