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Intraperitoneal rupture means the peritoneum has been penetrated and urine extravasates intra-abdominally.
Retinol-binding protein (RBP) is an 18,000-Da protein that extravasates readily when vascular permeability is enhanced by the acute-phase response.
In both interstitial and necrotizing pancreatitis fluid commonly extravasates from the pancreas and collects in the space surrounding it.