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Related to fatigable: fluctuant
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Firdapse is Catalyst's investigational drug candidate for the symptomatic treatment of Lambert Eaton myasthenic syndrome (LEMS), a rare, debilitating and sometimes life-threatening autoimmune, neuromuscular disorder, and congenital myasthenic syndromes (CMS), a rare neuromuscular disorder comprising of a spectrum of genetic defects and is characterized by fatigable weakness of skeletal muscles with onset at or shortly after birth or early childhood.
The nystagmus has a short latency (2-15 seconds), builds to a maximum, lasts <40 seconds, and is fatigable (wears off after repeated tests).
Typical histological changes include muscle atrophy, changes in myofibrillar protein composition with increase in the proportion of type II fatigable fibers, decreases in oxidative enzymes (type I fibers), and reductions in mitochondrial size and number (15,16).
Myasthenia gravis is an autoimmune disorder of neuromuscular signal transmission, resulting in fatigable weakness that commonly involves the ocular muscles and can also involve the respiratory muscles.
Fast twitch fibers are highly fatigable and the response of adjusting FES parameters may be different than in persons with acute SCI.
At least a five-second muscle relaxation period should be used between each contraction because easily fatigable muscles need a chance to recover, without permitting excessive rest periods for strong muscles.
Nous avons travaille d'arrache-pied, avec un rythme fatigable. Nous avons consacre une annee et demie pour l'ecriture du scenario sous l'oeil vigilant des historiens.
Fluctuating fatigable skeletal muscle weakness is usually diagnostic of MG.