Fixed drug eruption
: pathogenesis and diagnostic tests.
Keywords * Ondansetron * Hyperpigmentation * Fixed drug eruption
* 5HT3 receptor antagonists
TMP/SMX is a known cause of fixed drug eruptions
and other adverse drug reactions and cannot be legally dispensed in the United States without a prescription.
Conclusion: Fixed drug eruption
and urticaria without angioedema were commonest eruptions while, sulfonamides and NSAIDs were the major causative drugs.
Ingen-Housz-Oro et al., "Prognosis of generalized bullous fixed drug eruption
: comparison with Stevens-Johnson syndrome and toxic epidermal necrolysis," British Journal of Dermatology, vol.
The commonest drug reaction was found to be fixed drug eruptions
(29.2%) followed by urticaria (20.7%).
The differential diagnosis for HSV infection includes primary syphilis, chancroid, folliculitis, and fixed drug eruptions
Drug-Induced Skin Reactions Drug-Induced Skin Reactions (N = 52) N (%) Morbilliform Drug Eruption 26 (50%) Stevens-Johnson Syndrome 11 (21%) Toxic Epidermal Necrolysis 5 (10%) DRESS 5 (10%) Fixed Drug Eruption
2 (4%) Purpuric Drug Eruption 1 (2%) Acneiform Drug Eruption 1 (2%) Bullous Drug Eruption 1 (2%) DRESS: Drug Reaction with Eosinophilia and Systemic Symptoms
The first reported case of fixed drug eruption
by Bourns in 1889, described a series of sharply circumscribed, hyperpigmented lesions on the lips and tongue in a patient who had ingested antipyrine.
Fixed drug eruption
(FDE) is an adverse cutaneous drug reaction that recurs at the same site of the skin or mucous membrane after repeated exposure to the offending drug.
Rosen's patients had adverse reactions to doxycycline, one experiencing a fixed drug eruption
and one urticaria.
Miami Bureau Cutaneous Reaction Patterns to Drugs Clinical Pattern Selected Drug Examples Acneiform lithium, corticosteroids, androgens Lichenoid thiazides, antimalarials, captopril Fixed drug eruption
tetracyclines, sulfonamides, barbiturates Morbilliform beta-lactam antibiotics, calcium channel blockers Urticarial beta-lactam antibiotics, aspirin Pityriasis rosea-like captopril, gold Pigmentation minocycline, antimalarials, bleomycin Subacute lupus-like hydrochlorothiazide, terbinafine Systemic lupus-like procainamide, hydralazine, minocycline Serum sickness-like cefaclor, minocycline Pemphigus-like captopril, penicillamine Pseudoporphyria naproxen, furosemide Photosensitivity doxycycline, thiazides, sulfonylureas Source: Dr.