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Serious side effects associated with fluoroquinolone use include hallucination, depression, suicidal thoughts, tendinitis and tendon rupture, a "pins and needles" feeling in the arms and legs, joint pain and swelling, skin rash, and severe diarrhea.
Similarly, fluoroquinolones are not recommended as first-line agents in uncomplicated urinary tract infections.
The FDA added that, for some serious bacterial infections, the benefits of fluoroquinolones outweigh the risks, and it is appropriate for them to remain available as a therapeutic option.
The FDA had previously communicated safety information associated with systemic fluoroquinolone antibacterial drugs in August 2013 and July 2008, and the safety issues described in the current warning were discussed at an FDA Advisory Committee meeting in November 2015.
The primary findings were as follows: a majority (60%) of reported cases were "Highly suggestive" of a potential causal relationship between antibiotic treatment and psychosis, including 3 cases with a recurrence of psychosis after re-challenge with the same antibiotic; 3 different classes of antibiotics were implicated in this association, including fluoroquinolones, penicillins, and trimethoprim-sulfamethoxazole; for most of the reported cases, both the onset and resolution of psychosis occurred within 1 week of initiation and discontinuation of the antibiotic, respectively.
Since their introduction, fluoroquinolones are considered to be a basis in the combating of bacterial infections.
Unfortunately, that's exactly the case with the class of antibiotics called fluoroquinolones.
A situation beyond UTI where an oral fluoroquinolone such as ciprofloxacin might be considered is in the setting of Pseudomonas aeruginosa osteomyelitis.
A progressive increase in fluoroquinolone use and its association with increase in resistance against organisms other than M.
Fluoroquinolone resistance in Mycobacterium tuberculosis: the effect of duration and timing of fluoroquinolone exposure.
Using the TennCare pharmacy database, they obtained information on patients' use of fluoroquinolone for the 12 months prior to a TB diagnosis.
If you decide to prescribe an antibiotic because of severity of illness or duration of symptoms, a beta-lactam will work as well as a fluoroquinolone.