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The emergence of fluoroquinolone nonsusceptible strains that are resistant to third-generation cephalosporins, such as ceftriaxone, in Pakistan and other countries complicates typhoid fever treatment.
Considering these findings, the agency will strengthen warning labels on all fluoroquinolones, which already warn that the antibiotics may cause hypoglycemia and mental health issues, especially in older people, the FDA said in a press statement.
The use of fluoroquinolones has a place in the treatment of serious bacterial infections such as certain types of bacterial pneumonia where the benefits of these drugs outweigh the risks, and they should remain available as a therapeutic option.
The report "[urges] patients and health care professionals to report side effects involving fluoroquinolones or other drugs to the FDA MedWatch program."
None of the 64 isolates cultured were resistant to piperacillin-tazobactam but sensitive to fluoroquinolones. This suggests there is no additional coverage or benefit conferred with empiric Pseudomonas double coverage with an antipseudomonal beta-lactam and an antipseudomonal fluoroquinolone in our hospital population.
Similarly, fluoroquinolones are not recommended as first-line agents in uncomplicated urinary tract infections.
The FDA had previously communicated safety information associated with systemic fluoroquinolone antibacterial drugs in August 2013 and July 2008, and the safety issues described in the current warning were discussed at an FDA Advisory Committee meeting in November 2015.
Here, we report a relatively high rate (12.4%) of fluoroquinolone nonsusceptible isolates and high resistance to levofloxacin (2%) among serotypes V and IV CC1 GBS strains causing adult invasive diseases.
During identification of the genetic determinants of fluoroquinolone resistance in STM1, a shotgun genomic library of this mutant strain was constructed using plasmid pUC19 as the cloning vector.
Our study will be first of its kind as no other prospective cohort study on the use of fluoroquinolones and its relation to development of psychosis has yet been carried out despite of the large number of cases.
Since their introduction, fluoroquinolones are considered to be a basis in the combating of bacterial infections.
If an antibiotic is necessary, make sure you take a different type of antibiotic, not a fluoroquinolone. You'll recognize these drugs because their names end in "-floxacin," such as ciprofloxacin.