However, accumulation of high levels of cholesteryl ester may lead to the formation of foam cells
and, later, to atherogenesis.
On the basis of post hoc Duncan test, it has been found that there is a difference in foam cell
number between normal diet group for 8 weeks and normal diet group for 16 weeks.
14) These foam cells
then die, creating debris that fill the inflamed tissue and perpetuate even more inflammation.
In aorta of animals of group B, H and E stained slides displayed that in addition to intracellular lipid accumulation in foam cells
present mostly in intima, pools of extra cellular lipids were also visible in deeper layers.
They are characterized by the accumulation of foam cells
in the internal elastic membrane, while the endothelial surface is intact.
These results suggest a critical role of TREM-1 in foam cell
formation and the pathogenesis of atherosclerosis and may aid in the design and development of new strategies to combat atherosclerosis.
The macrophages get clogged with cholesterol and become what scientists call foam cells
, which are one of the earliest markers of atherosclerosis.
Macrophage foam cells
are a source of mediators, including other cytokines and effector molecules, such as hypochlorus acid, superoxide anion, and matrix metalloproteinases.
Macrophages play a key role in atherogenesis by releasing proinflammatory cytokines and forming foam cells
in subendothelial lesions.
When polyurethane foam is made, a thin membrane of polyurethane material encapsulates the foam cells
, preventing the passage of gases or liquids through the foam.
In regard of the foam cell
nucleation density, the most dominant factor was the injection volume, as shown in Fig.
This material forms a uniform foam cell
size where at least 90% of the foam cells
are 50 micrometers or less.