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Folinic acid acts as a synergistic agent, helping fluorouracil to inhibit thymidylate synthase.
Folic Acid and Folinic Acid: Combating GI Toxicity, Hepatic Transaminase Elevations, and Hair Loss
The patient was commenced on treatment for toxoplasmosis, which involves a six-week course of antimicrobial therapy including sulfadiazine, pyrimethamine, and folinic acid. She responded well to treatment and her confusion resolved.
She also received 50mg of methotrexate every other day (04 doses) with 5mg of folinic acid each day proceeding the methotrexate.
She received three courses of mFOLFOX6 regimen (oxaliplatin, folinic acid, and fluorouracil) as neoadjuvant chemotherapy, followed by resection of the peritoneal dissemination and partial resection of the vagina.
Previous studies of folic acid, folinic acid, and L-Methylfolate support this contention.
After initiation of LCV (folinic acid) at 42 h she was noted to have hypersensitivity reaction.
(7.) Efficacy of adjuvant fluorouracil and folinic acid in colon cancer.
All patients were treated with oral prednisone (1mg/kg/day for one week, followed by tapering doses), pyrimethamine (25 mg/day), sulphadiazine (1 g four times per day), and folinic acid (7.5 mg/day) for 35 days, according to the protocol of the Uveitis Section, Department of Ophthalmology, Universidade Federal de Minas Gerais, Brazil.
[33] 2 57 1 40 Note: CAPOX, capecitabine 2000 mg/[m.sup.2] 14/21 days and oxaliplatin 130 mg/[m.sup.2] 1/21 days; FOLFOX6 (1), oxaliplatin 100 mg/[m.sup.2] 1/14 days, folinic acid 400 mg/[m.sup.2] 1/14 days, 5/FU 400 mg/[m.sup.2] 1/14 days, and 5/FU 2000 mg/ [m.sup.2] CVI over 46 h/14 days.
She was started on adjuvant chemotherapy with FOLFOX (5FU + folinic acid + oxaliplatin).
As a result, the chemotherapy regime was switched to bolus fluorouracil (5 FU) and folinic acid. This was continued for three cycles.