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Softgel formulations are typically considered for poorly soluble APIs, in order to take advantage of lipid solubility, or as line extensions to marketed drugs.
Evolving DDS media from first-generation 2GB products to the 36GB capacity of the new DAT 72 format is the result of consistent improvements in metal particle formulations, thinner media and improved base films.
Figure 1 shows how much impact an increase in formulation solids can have on sheet moisture and ultimately line speeds.
VIDEX EC is an enteric coated, once daily formulation, which, in combination with other antiretroviral agents, is indicated for the treatment of HIV-1 infection in adults whose management requires once-daily administration of didanosine or an alternative didanosine formulation.
In a study comparing saquinavir soft-gel/NRTIs versus saquinavir hard-gel/NRTIs, on-treatment analysis showed that at 16 weeks 67% of' patients on the soft-gel formulation compared to 37% of patients on the hard-gel formulation had viral loads below 400 copies/mL.
It performs reflectance and transmittance measurements in either a standalone mode using its built-in software, or interfaced to a PC with the company's new WinMatch QC and formulation software for Windows 95.
In their 16-week, double-blind, placebo-controlled study of 201 men and women with elevated LDL levels, the new formulation achieved niacin's typical cholesterol reductions -- with almost no ill effects.
EpiTan Limited (ASX: EPT, ADR: EPTNY, XETRA: UR9), Melbourne, Australia has announced that approval has been obtained from the UK's regulatory agency - The Medicines and Healthcare products Regulatory Agency (MHRA) - to begin a human trial for a newly developed topical formulation for its melanin-inducing drug Melanotan.
There ate many factors that should be taken into consideration when determining what composite mix formulation should be used:
Overall compounds based on K1446A and reduced oil performed better than the control formulations with oil.
Special uv stabilizer formulations are provided for PE, PP and polybutylene films.