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Related to gene switch: Gene activation
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The insect hormone ecdysone may provide the most effective gene switch yet, suggest investigators from the Howard Hughes Medical Institute at the Salk Institute for Biological Studies in La Jolla, Calif., and the University of California, San Diego (UCSD).
The researchers used a gene switch known as estrogen-related receptor gamma (ERR gamma) that when activated in fast twitch fibers of mice by genetic engineering, converts these fibers into slow twitch fibers.
To date, biotechnologists had attempted to build such digital circuits with the help of protein gene switches in cells.
A technique developed in the Chang laboratory called ATAC-seq identifies gene switches that are turned on in mouse skeletal stem cells in response to the mechanical force of distraction.
It has only one claw and is roughly between 7 and 8 inches long because the gene switches on when the embryo's wings are developing, thus reducing their size.
Researchers say there are at least four million such gene switches in the genome, and that many human diseases seem to be caused by changes in the switches.