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Related to gene switch: Gene activation
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In most of the tissue samples of melanomas of all stages they found alterations in the telomerase gene switch, which the researchers clearly identified as typical consequences of sun exposure.
ZIN-CTI-001, the Company's most advanced synthetic biology product candidate, employs autologous dendritic cells (DC) transduced with a controllable gene switch, and a gene for expressing Interleukin-12 (IL-12), a potent anticancer protein.
Using RTS technology, IL-12 expression is regulated using a controllable gene switch, which is activated by an orally-delivered small-molecule activator ligand (AL).