Apparently for many, adult onset idiopathic generalized epilepsy
(AOIGE) is localization related epilepsy related to traumatic brain injury sustained in the recent past or may represent unrecognized childhood or adolescence epileptic symptoms.
Volumetry of the thalamus in idiopathic generalized epilepsy
. Archives of Neuropsychiatry-Noropsikiyatri Arsivi 2011; 48:243-248.
CBZ (n:14 - 29.2%) In VPA group, 33 (97.1%) women had idiopathic generalized epilepsy
with generalized tonoc-clonic seizures and one (2.9%) had cryptogenic generalized tonoc-clonic epilepsy.
The newer agents are indicated for add-on therapy of partial seizures, as well as for primary generalized epilepsy
among patients who have weight gain or other difficulties with an older drug.
Meanwhile, the results of an Asia-Pacific (Japan, China, South Korea, India, Australia) regional sub-group analysis of Study 332,1 a global study of primary generalized tonic-clonic (PGTC) seizures in patients with generalized epilepsy
, were also presented at this same congress meeting.
Neuropathological findings in primary generalized epilepsy
: a study of eight cases.
In a study of 114 children with complex partial seizures or primary generalized epilepsy
, 60% should have received a psychiatric diagnosis according to the results of four different tests, but only 33% of those children ever received any recognition of or treatment for their psychiatric needs.
In a study with 94 women with epilepsy and 23 control women, those who had primary generalized epilepsy
and were treated with valproate had a 55% prevalence of ovulatory failure, said Dr.
"Adjunctive Perampanel for Treatment of Drug-Resistant Primary Generalized Tonic-Clonic Seizures in Patients with Idiopathic Generalized Epilepsy
: A Double-Blind, Randomized, Placebo-Controlled Phase III Trial."
Similarly an MRI "should be seriously considered in any child with a significant cognitive or motor impairment of unknown etiology unexplained abnormalities on neurologic examination, a seizure of partial (focal) onset with or without secondary generalization, [or] an EEG that does not represent a benign partial epilepsy of childhood or primary generalized epilepsy
, or in children under 1 year of age," the practice parameter states.
has received a positive opinion from the European Medicines Agency's Committee for Medicinal Products for Human Use (CHMP) for the use of Fycompa (perampanel) for the adjunctive treatment of primary generalized tonic-clonic (PGTC) seizures in adult and adolescent patients from 12 years of age with idiopathic generalized epilepsy
Primary generalized tonic-clonic (PGTC) seizures are one of the most common and most severe forms of generalized seizures, accounting for approximately 60% of generalized epilepsy
and approximately 20% of all epilepsy cases.(2) For the majority of patients, a PGTC seizure begins with a loss of consciousness without any prior warning symptoms and a sudden contraction of the tonic muscles, causing the patient to fall down (tonic phase).