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gist

(Ground for a suit), noun alleged reason, base, basis, basis of argument, basis of litigation, cardinal point, cause, cause of action, essential ground, essential matter, essential part, focal point of the complaint, foundation of a suit, gravamen, gravamen of a charge, gravamen of the complaint, great point, ground, important point, keystone, main charge, main point, object of the action, pith of a matter, point, principal part, principal point, reason, reason for which suit is commenced, salient point, substance, substantial part of a complaint, sum and substance, ultimate cause
Associated concepts: gist of a cause of action, gist of an offense, gist of the complaint

gist

(Substance), noun backbone, basis, broad meaning, connotation, core, drift, essence, essential meaning, essential part, fundamentals, general meaning, idea conveyed, import, index, intrinsic nature, marrow, matter, pith, primary meaning, purport, quiddity, quintessence, real content, reality, root, sense, spirit, substantial meaning, sum and substance, tenor, true meaning, vital principle
See also: center, connotation, content, contents, context, essence, gravamen, import, main point, meaning, significance, signification, spirit, subject, substance, sum, tenor

gist

the essential point of an action.

GIST, pleading. Gist of the action is the essential ground or object of it, in point of law, and without which there is no cause of action. Gould on Pl. c. 4, Sec. 12. But it is observable that the substance or gist of the action is not always the principal cause of the plaintiff Is complaint in point of fact, nor that on which he recovers all or the greatest part of his damages.
     2. It frequently happens that upon that part of his declaration which contains the substance or gist of the, action, he only recovers nominal damages, and he gets his principal satisfaction on account of matter altogether collateral thereto. A familiar instance of this is the case where a father sues the defendant for a trespass for the seduction of his daughter. The gist of the action is the trespass, and the loss of his daughter's services, but the collateral cause is the injury done to his feelings, for which the principal damages are given. In stating the substance or gist of the action, every thing must be averred which is necessary to be proved at the trial. Vide 1 Vin. Ab. 598; 2 Phil. Ev. 1, note. See Bac. Abr. Pleas, B; Doct. P. 85. See Damages, special, in pleading; 1 Vin. At. 598; 2 Phil. Ev. 1, n.

References in periodicals archive ?
Although most GISTs are negative for desmin, rare cases do express desmin, which may lead to misclassification as a smooth muscle tumor.
The results showed that doubling the daily dose of Glivec may improve progression-free survival of patients with KIT (CD117)-positive inoperable and/or metastatic** GIST.
AMG 706 is being evaluated as both a monotherapy and in combination with other agents for the treatment of various cancers, including imatinib-resistant GIST, non-small cell lung cancer and colorectal cancer.
This situation changed drastically in 1998, when Hirota and colleagues (6) discovered that most GISTs harbored c-kit mutations that resulted in full-length KIT proteins with ligand-independent activation.
c-kit expression by immunohistochemistry is considered a key diagnostic feature in GISTs and is seen in most of these tumors.
2,4] However, case reports of GISTs describing remarkable whorl formations throughout the whole area of the tumor, as in our case, are extremely rare.
Gleevec is now the only post-surgery treatment indicated to delay the return of this highly aggressive cancer, filling a major need for GIST patients.
Twenty-seven cases of GISTs were collected for 14 years (1985-1999), including 8 benign (leiomyoma), 15 malignant primary (leiomyosarcoma), and 4 metastatic to the liver.
An article in the June issue of The Oncologist looks at recent research into the reasons for this imatinib resistance -- including results that may open the way to individualized treatment for GIST in the near future.
While the majority of activating mutations in GIST are found in a different gene -- the KIT gene, GISTs with mutations in PDGFRA represent a subset that poses new challenges in diagnosis and treatment.
The results showed that doubling the daily dose of Gleevec may improve progression-free survival of patients with KIT (CD117)-positive inoperable and/or metastatic** GIST.
Glivec continues to improve the standard of care in GISTs, where it has altered the natural course of the disease and dramatically improved patients' lives.