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Related to glomerular filtration barrier: Bowman's capsule, urinary space, Glomerular capillaries
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The underlying pathology is thought to occur at the glomerular filtration barrier with intact tubular function.
As podocytes play an important role in the structural and functional integrity of glomerular filtration barrier (GFB), any injury to the podocyte not only affects the structure of the podocyte or SD, but also disrupts the adjacent structures and consequently alters glomerular perm selectivity to the macromolecules in the blood.
Many genes that are highly expressed in glomerular filtration barrier (GFB), especially the podocytes and slit diaphragms (SD), have been implicated.