Accumulation of protease-resistant prion protein (PrP) and apoptosis of cerebellar granule cells
in transgenic mice expressing a PrP insertional mutation.
Rodent and primate studies have shown that new granule cells
are being added to the hippocampus throughout life, that neurogenesis is required for normal brain function, that chronic stress and prolonged depressive states inhibit hippocampal neurogenesis, and that reduced neurogenesis correlates with slower learning.
19 in Neuron that molecular disruptions in small neurons called granule cells
- located in the dentate gyrus region of the brain - caused brain seizures in mice similar to those seen in human temporal lobe epilepsy.
In rats, 6 percent of the total granule cell
population is produced each month by NSCs that have divided and differentiated into neurons.
KEY WORDS: cerebellum, DNA damage, granule cell
, HN2, MAM, methylazoxymethanol, nitrogen mustard.
Morgan's team found that nerves in the cerebellum called granule cells
release a protein called Cbln1 from their axons.
Unbiased estimate of hippocampal granule cell
numbers in hypothyroid and in sex-age-matched controls.
relay the information they receive from neurons involved in memory and cognition back to the olfactory bulb.
Immunohistochemical markers were used to identify the new cells which included excitatory granule cells
, astrocytes, and a very small number of the interneurons.
Researchers from the Department of Pharmacology, Nippon Medical School, showed that chronic treatment of adult mice with fluoxetine (Prozac) caused changes to granule cells
, one of the main types of neuronal cells inside the hippocampus, and to their connections with other neuronal cells.
When oxidative stress was induced in suspension of cerebellum granule cells
by their incubation with N-methyl-D-aspartate (NMDA), or hydrogen peroxide (H(2)O(2)), both STC and RTC more efficiently decreased accumulation of reactive oxygen species (ROS) than carnosine and trolox.
A] receptors subunits expression and chloride influx were investigated in cultured cerebellar granule cells