Human amniotic epithelial cells can differentiate into granulosa cells
and restore folliculogenesis in a mouse model of chemotherapy-induced premature ovarian failure.
Adult granulosa cell
tumour-like areas occurring in ovarian epithelial neoplasms: Report of a case series with investigation of FOXL2 mutation status.
Thecomas occur at a slightly older age on average than the granulosa cell
tumor and do not have as wide a gross spectrum, being typically smaller with a more exquisitely yellow solid sectioned surface, but exceptions occur.
Bcl-2 is expressed in granulosa cells
of both fetal and adult ovaries.
It was important to understand if this herb affected the oocytes or their supporting granulosa cells
that are critical for reproduction.
The developmental stages of follicles have been defined previously (2) as: i) primordial (one layer of flattened granulosa cells
around the oocyte); ii) transitional (one layer of flattened to cuboidal granulosa cells
around the oocyte); iii) primary (a single layer of cuboidal granulosa cells
); iv) secondary (two or more layers of cuboidal granulosa cells
Kim et al., "Surgical staging and adjuvant chemotherapy in the management of patients with adult granulosa cell
tumors of the ovary," Gynecologic Oncology, vol.
Tamoxifen may increase the levels of estrogen by interfering with the normal negative pituitary feedback mechanism  and by its direct effect with ovarian granulosa cells
Guignot et al., "Effect of adiponectin on bovine granulosa cell
steroidogenesis, oocyte maturation and embryo development," Reproductive Biology and Endocrinology, vol.
miR-34a targets the inhibin beta B gene, promoting granulosa cell
apoptosis in the porcine ovary.
In another study histological observations of folliculogenesis and follicular atresia in immature female rats (0-35 days old) were studied; after day 30 numerous primary follicles and atretic follicles were observed in the ovaries, antrum grew larger in the follicles where oocyte disappeared and granulosa cell
layer became thin.8