Using genetic tools in mice, researchers at Johns Hopkins Medicine say they have identified a pair of proteins that precisely control when sound-detecting cells, known as
hair cells, are born in the mammalian inner ear.
Santos-Sacchi, "Reversible inhibition of voltage-dependent outer
hair cell motility and capacitance," The Journal ofNeuroscience, vol.
The effect of topical Castellani solution on outer
hair cell function of rats.
RT-PCR revealed that differentiated cells expressed
hair cells specific genes.
Mechanistically, the intense metabolic activity induced by noise stimulation may make
hair cells undergo oxidative stress, resulting in the cell death leading to noise-induced hearing loss (NIHL).
To observe the effect of Type 2 diabetes on functional status of outer
hair cellsThese integrated mIESCs expressing a
hair cell marker were not able to replace the complex cytoarchitecture of the OC (Figure 3).
The proportion of missing
hair cells did not increase at the same rate as damaged
hair cell bundles, suggesting that neomycin treatment, at first, might not be causing the
hair cells to undergo cell death by either apoptosis or necrosis, but rather that aminoglycoside treatment damages the
hair cells in a nonlethal manner at these concentrations.
Whereas previous research indicated that
hair cells are not replaced, this latest study found that replacement does indeed occur, but at very low levels.
Abortive synaptogenesis as a factor in the inner
hair cell degeneration in the Bronx Waltzer (bv) mutant mouse.
biotech GenVec to develop gene-based treatments to replace
hair cells in the ear that transmit sound.
Tsukruk and two graduate students, Michael McConney and Kyle Anderson, conducted preliminary experiments with a simple artificial
hair cell microsensor made of a common epoxy-based polymer capable of solidifying.