When lamivudine was given at the time of exacerbation, no difference in mortality due to hepatic insufficiency
was observed between treated and untreated patients (9% vs.
Factors triggering simvastatin myopathy Factor NP CK Myalgia Weakness Drugs Colchicine 1 + + Fusidic acid 1 + Verapamil/cyclosporine 1 + Cortisone azathioprine, cyclosporine 1 + Amiodarone 2 + + + Nefazodone 1 + Danazol/renal failure 1 + Clarithromycin 2 + + + Itraconazole/cyclosporine 1 + Itraconazole/gemfibrozil, cyclosporine 1 + Tacrolimus/fusidic acid 1 + Diltiazem 1 + Fibrates 1 + Fluconazole 1 + + Nelfinavir 1 + + Ritonavir 1 + ng ng Indomethacin/renal failure 1 + ng ng Troglitazone 1 + Conditions Diabetes 1 + + Renal insufficiency ng + Hepatic insufficiency
ng + Hypothyroidism ng + Muscle activity ng + NP, Number of patients; CK, creatine kinase; ng, not given.
In general, the hypoglycemic effect of metformin will only be seen in diabetics unless one simultaneously ingests another hypoglycemic agent or if he has co-existing severe hepatic insufficiency
as seen in this case.
After liver resection, a degree of hepatic insufficiency
can result in reduced levels of procoagulant and anticoagulant factors normally synthesised in the liver.
213U/L, coagulopathy, ascitis and some degree of disorientation, suggested an investigation of contributing pathologies, which lead to a diagnosis of hepatic insufficiency
Consider selecting an antibiotic other than a fluoroquinolone for an elderly patient with diabetes mellitus (especially those taking sulfonylureas), hepatic insufficiency
, or renal insufficiency (A).
The risk increases with conditions such as sepsis, dehydration, excess alcohol intake, hepatic insufficiency
, renal impairment, and acute congestive heart failure.
These findings suggest that Lantana camara within the liver might have induced hepatic insufficiency
thereby resulting in secondary photosensitization when these buffaloes were exposed to sunlight.
Monitor hepatic function if used beyond 1 month and in patients with signs of hepatic insufficiency
It occurs only in patients with severe hepatic insufficiency
, decreased resistance to infection, and high-volume/low-protein ascites.
Accordingly, metformin is contraindicated in congestive heart failure, in the presence of renal or hepatic insufficiency
, during periods of hypoxemia or dehydration, and for heavy alcohol drinkers.
Potassium excretion is increased initially upon administration of methazolamide and in patients with cirrhosis or hepatic insufficiency
could precipitate a hepatic coma.