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Related to hepatic insufficiency: renal insufficiency, liver insufficiency
References in periodicals archive ?
The degree of hepatic insufficiency depends in part on the extent of the resection.
There is no clinical experience in patients with severe (Child-Pugh score >9) hepatic insufficiency.
Other occasional adverse reactions include urticaria, melena, hematuria, glycosuria, hepatic insufficiency, flaccid paralysis, photosensitivity, convulsions, and, rarely, crystalluria and renal calculi.
caution in patients with hepatic insufficiency or with impaired renal function.
It occurs only in patients with severe hepatic insufficiency, decreased resistance to infection, and high-volume/low-protein ascites.
After a single oral dose of posaconazole 400 mg, the mean AUC was 43%, 27% and 21% higher in subjects with mild (Child-Pugh Class A, N=6), moderate (Child-Pugh Class B, N=6), and severe (Child-Pugh Class C, N=6) hepatic insufficiency, respectively, compared to subjects with normal hepatic function (N=18).
VIMOVO is not recommended in patients with severe hepatic insufficiency.
In addition, two higher risk patient subgroups completed the study, approximately 40 patients with mild-to-moderate renal insufficiency and approximately 40 patients with mild hepatic insufficiency.
Kaletra should not be given to patients who have had an allergic reaction to the active substances or any of the excipients, or by patients with severe hepatic insufficiency.
No dosage adjustment is needed for patients with mild to moderate hepatic insufficiency or in patients with mild renal insufficiency (CrCl 50 mL/min).
adjustments based on gender, race, age, HIV status, hepatic insufficiency or