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Currently, for non-responders to a combination of PEG and ribavirin, there is no consensus therapeutic option that considers the histological response among treatment efficacy end-points [3,9-11].
Stabilization of fibrosis has also been observed in non-responder patients after treatment with interferon-alpha [28], a fact that could be indicative of histological response since progression of fibrosis is expected to be the natural course of chronic hepatitis.
Main outcome measures included clinical response, change in lesion area and histological responses.