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The numerous reports on alkaptonuria are limited to degenerative manifestations in joints, but there are very few reports of the effects of the deposition of homogentisic acid in tendons leading to spontaneous rupture.
A common symptom of alkaptonuria, ochronosis is the result of excess homogentisic acid (HGA) due to the autosomal recessive mutation of the homogentisate 1, 2-dioxygenase (HGO) gene on chromosome 3.
26) In that case, needle biopsy material displayed dark brown homogentisic acid deposition in both the corpora amylacea and prostatic epithelium, but again not in the stroma.
Fifteen standard phenolic compounds, including gallic acid, pyrogallol, homogentisic acid, protocatechuic acid, (+) catechin, chlorogenic acid, caffeic acid, vanillin, ferulic acid, naringin, resveratrol, naringenin, hesperetin, formononetin, biochanin-A were purchased from Sigma Aldrich and used for calibration curves.