rejection

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References in periodicals archive ?
Moller, "Hyperacute rejections of two consecutive renal allografts and early loss of the third transplant caused by non-HLA antibodies specific for endothelial cells" Transplant Immunology, vol.
They provoke hyperacute rejection. That's because the surfaces of porcine endothelial cells, which line the blood vessels of the donar organs, sport molecules that their human counterparts don't.
Xenograft failure in this time period was not due to hyperacute rejection as the explanted hearts show vascular antibody deposition but otherwise normal myocardial histology [100].
The development of [alpha]1,3Gal deficient pigs expressing human complement regulatory proteins such as hDAF, MCP, and CD59 is necessary to overcome hyperacute rejection of pig organs transplanted into non-human primates by gene targeting technology.
In the field of transplantation, it has been used to globally reduce the overall level of antibodies in transplant candidates (Alarabi et al., 1997; Harano et al., 1999) and has been used precisely to remove donor specific antibodies that would cause hyperacute rejection or acute antibody-mediated rejection (Montgomery et al., 2000; Takeda et al., 2000; Zachary, Ratner,& Lefell, 2001).
Four healthy piglets are born without the gene--alpha 1, 3 galactose- responsible for making an enzyme that adds sugar to the surface of pig cells that leads to hyperacute rejection of the pig organ.
The most profound barrier to pig-to-primate xenotransplantation is the rejection of the grafted organ by a cascade of immune mechanisms commonly referred to as hyperacute rejection (HAR), acute vascular rejection (AVR)/humoral xenograft rejection (AHXR), immune cell-mediated rejection, and chronic rejection.
The 4 healthy piglets were born without the gene--alpha 1, 3 galactose- responsible for making an enzyme that adds sugar to the surface of pig cells which is recognized by the human immune system as foreign which in turn leads to hyperacute rejection of the pig organ.
Prevention of hyperacute rejection by removal of antibodies to HLA immediately before renal transplantation.
The rejection of donor organs is a barrier even in human-to-human transplantation, one addressed by immunosuppressive drugs such as cyclosporine; hyperacute rejection, in which donor organs are rapidly destroyed, poses an even greater barrier in animal-to-human transplants.
Qian et al., "The effect of FK-506 on hyperacute rejection in presensitized rats," Transplantation Proceedings, vol.
This induces complement activation and results in hyperacute rejection of the xenograft (Good et al., 1992; Galili, 1993; Sandrin et al., 1993; Tanemura et al., 2000).