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Research suggests that GMCSF may stimulate immune responses and improve viral control in HIV patients.
Their immune responses were then followed as they were given B-6 at ever-increasing doses.
We have elected to focus on the use of mice largely because for this species there is a sophisticated appreciation of the immune response, coupled with the availability of a range of reagents.
Silvera, PhD, of the Southern Research Institute in Frederick, Maryland, showed that Remune when given with a fancy adjuvant called CpG causes uninfected monkeys to develop two key immune responses against HIV -- antibody and t-cell responses.
The first kind is composed of various cell types, including NK cells and antibody-dependent cytotoxicity, and functions very early in the immune response (day 1 to 3), and these cells are detected through out the mucosal immune system.
Improvements in immune response among those who are optimistic may be due to lower levels of stress.
Moreover, a strong anti-HIV immune response in no way predicted low post-trial viremia; to the contrary, patients with strong stimulation of anti-HIV immune responses tended to have higher, not lower, viremia after interruption of therapy.
Onyvax-P is a therapeutic prostate cancer vaccine designed to elicit a powerful and specific immune response against prostate cancer cells without the severe side effects often associated with conventional cancer therapies.
With a better understanding of the immune response, these intriguing results might offer new directions for therapy and vaccines.
And after 8 weeks, all of the original virus was gone--showing the effect of the immune response.