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There are several concerns regarding biologics in the treatment of immune-mediated inflammatory diseases.
Guselkumab is a human monoclonal antibody that targets interleukin (IL)-23, a protein which has been shown to play a key role in the development of immune-mediated inflammatory diseases.
In addition, Intellikine recently entered into a $489 million collaborative partnership with Infinity Pharmaceuticals July 2010 to develop oral therapies targeting PIK3K and PI3K for indications including immune-mediated inflammatory diseases and cancer.
The purpose of the investments is to advance Ugimer drug development for immune-mediated inflammatory diseases or IMID.
Vertex plans to pursue collaborative opportunities for VX-509 with major pharmaceutical companies to more fully capture the potential value of the compound across multiple immune-mediated inflammatory diseases.

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