imprecision


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Imprecision and bias are the major contributors of MU for quantitative assays.
Estimation of uncertainty measurement - A prerequisite of ISO1589 accreditation for clinical laboratories
According to the National Cholesterol Education Program, for cholesterol the allowed bias is [+ or -] 3% and imprecision is [+ or -] 6%.
Assessing the Impact of Analytical Error on Perceived Disease Severity
One hundred patients were modeled at each combination of bias and imprecision for 100 h with each treatment regimen.
Effects of measurement frequency on analytical quality required for glucose measurements in intensive care units: assessments by simulation models
On balance, imprecision in the measurement of key economic magnitudes does complicate the job of policymaking.
Statement by Alan Greenspan, Chairman, Board of Governors of the Federal Reserve System, before the Commerce, Consumer, and Monetary Affairs Subcommittee of the Committee on Government Operations, U.S. House of Representatives, August 10, 1994
The maximum bias in the expression is valid only in cases when the imprecision equals zero.
Gross overestimation of total allowable error based on biological variation
est]) for each result was calculated by linear interpolation from the intermediate imprecision QC data.
Outliers as a cause of false cardiac troponin results: investigating the robustness of 4 contemporary assays
65 X imprecision (CV%)], TEa lines are superimposed on each graph to demonstrate the percentage of insulin dosing errors that occur for the 10%, 15%, and 20% TEa conditions.
Glucose meter performance criteria for tight glycemic control estimated by simulation modeling
When assay validation is done properly, modest increases in imprecision above 10% (up to 25% CV) inherently increase the 99th percentile value and thus protect against false-positive values (6).
Being rational about (Im)precision: a statement from the biochemistry subcommittee of the joint European Society of Cardiology/American College of Cardiology Foundation/American Heart Association/World Heart Federation Task Force for the definition of myocardial infarction
It is confusing to present the 2 error sources, total imprecision, and random interferences as 1 combined error source, because these 2 error sources are quite different.
A recommended improvement for specifying and estimating serum creatinine performance
To use the 99th percentile irrespective of assay imprecision is an attractive suggestion because this would be simpler and less arbitrary than a 10% CV cutoff (which corresponds to a different cTnI concentration on every platform).
Mathematical modeling: assumptions affect results
We previously showed that a change in the theoretical imprecision profile of a cardiac troponin assay (i.
Influence of imprecision on ROC curve analysis forc cardiac markers
To investigate the influence of assay imprecision on the likelihood of misclassifying healthy individuals or patients without myocardial injury, we simulated the distribution of cardiac troponin I (cTnI) results in a general population and added random analytical error reflecting different assay imprecision profiles.
Validation of the 99th percentile cutoff independent of assay imprecision (CV) for cardiac troponin monitoring for ruling out myocardial infarction

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