Imprecision and bias are the major contributors of MU for quantitative assays.
According to the National Cholesterol Education Program, for cholesterol the allowed bias is [+ or -] 3% and
imprecision is [+ or -] 6%.
One hundred patients were modeled at each combination of bias and
imprecision for 100 h with each treatment regimen.
On balance,
imprecision in the measurement of key economic magnitudes does complicate the job of policymaking.
The maximum bias in the expression is valid only in cases when the
imprecision equals zero.
est]) for each result was calculated by linear interpolation from the intermediate
imprecision QC data.
65 X
imprecision (CV%)], TEa lines are superimposed on each graph to demonstrate the percentage of insulin dosing errors that occur for the 10%, 15%, and 20% TEa conditions.
When assay validation is done properly, modest increases in
imprecision above 10% (up to 25% CV) inherently increase the 99th percentile value and thus protect against false-positive values (6).
It is confusing to present the 2 error sources, total
imprecision, and random interferences as 1 combined error source, because these 2 error sources are quite different.
To use the 99th percentile irrespective of assay
imprecision is an attractive suggestion because this would be simpler and less arbitrary than a 10% CV cutoff (which corresponds to a different cTnI concentration on every platform).
We previously showed that a change in the theoretical
imprecision profile of a cardiac troponin assay (i.
To investigate the influence of assay
imprecision on the likelihood of misclassifying healthy individuals or patients without myocardial injury, we simulated the distribution of cardiac troponin I (cTnI) results in a general population and added random analytical error reflecting different assay
imprecision profiles.