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These conflicting results lend support to the conclusion that such methods for indirect comparisons may not be the most accurate due to several sources of confounding.
A meta-analysis of 62 placebo-controlled trials was performed for indirect comparisons between second-generation antidepressants, which showed a few statistically significant differences that were modest and "likely not clinically important," he added.
It is now accepted practice to publish all direct and indirect comparisons at both the NIST and the BIPM.
According to the indirect comparisons shown in Table 3, both ivy leaf suppositories and syrup were significantly superior to placebo as the 95% CIs of the point estimates for the mean difference between the treatments excluded zero.